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Back to: Our Providers / Biovision / BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant
Size
100 μg
Price
697.00
Catalog
7655-100
Quick and safe buy process
Background
The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRM is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin.
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Physical properties
50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.
Synonym
BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant
Notes
For Research Use Only! Not to be used in humans
Before use
Centrifuge the vial prior to opening.
Molecular weight
43.7 kDa (1367-1511 aa + NT GST Tag)
Additional source
Recombinants or rec. proteins
Other name
SMARCA2A/B; SWI/SNF ATPase
Tested applications
SDS-PAGE, HPLC
Group
recombinants
Source
E. coli
NCBI gene
SMARCA2
Shipping under
dry ice
Purification
≥95%
Physical appearance
Liquid
NCBI number
P51531
Storage condition
-80°C
Gene source
Human
NCBI gene number
6595
Aa sequence
N/A
How to reconstitute
N/A
Target
BRM
Unit
N/A
Binding ability
N/A
Reesults
N/A
Biological activity
N/A
Level of endotoxin
N/A
Recombinant
Yes
Concentration
N/A
Tested activity
N/A