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Back to: Our Providers / Biovision / BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant

Size

20 μg

Price

240.00

Catalog

7655-20

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Background

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRM is a member of the SWI/SNF protein family, which forms part of a large ATP-dependent chromatin remodeling complex. This complex is required for transcriptional activation of genes normally repressed by chromatin.

Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.

Physical properties

50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5% glycerol, and 5 mM β-mercaptoethanol.

Synonym

BRM bromodomain (1367-1511 aa) (GST-tagged), Human recombinant

Notes

For Research Use Only! Not to be used in humans

Before use

Centrifuge the vial prior to opening.

Molecular weight

43.7 kDa (1367-1511 aa + NT GST Tag)

Additional source

Recombinants or rec. proteins

Other name

SMARCA2A/B; SWI/SNF ATPase

Tested applications

SDS-PAGE, HPLC

Group

recombinants

Source

E. coli

NCBI gene

SMARCA2

Shipping under

dry ice

Purification

≥95%

Physical appearance

Liquid

NCBI number

P51531

Storage condition

-80°C

Gene source

Human

NCBI gene number

6595

Aa sequence

N/A

How to reconstitute

N/A

Target

BRM

Unit

N/A

Binding ability

N/A

Reesults

N/A

Biological activity

N/A

Level of endotoxin

N/A

Recombinant

Yes

Concentration

N/A

Tested activity

N/A

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