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Size

0.05 mg

Price

180.00

Catalog

49-809

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Gene info

PTHR1, a Parathyroid Hormone Receptor, mediates PTH-dependent regulation of mineral-ion homeostasis. It also mediates the paracrine action of PTHRP in endochondral bone formation. Mutations in this receptor are responsible for disorders of calcium and bone metabolism such as chondrodysplasia, hypercalcemia, and chronic renal failure. Three promoters, P1, P2, and P3, regulate the expression of PTHR.

About

Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.

Gene names

PTH1R, Parathyroid hormone 1 receptor, Parathyroid hormone receptor 1, PFE, Pth-related peptide receptor, PTHR, PTH/PTHr receptor, Pth/pthrp receptor, Parathyroid hormone receptor, PTH/PTHrP type I receptor, PTH1 receptor, PTHR1, PTHrP-R, PTHrP-receptor

Spicific to

Recognizes human PTH/PTHrP receptor, Mr 80kD, and the receptor dimer, Mr 160kD. A faint nonspecific band at 110kD is also detected. This antibody does not detect the PTH2 receptor.

Description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Keep at

PTHR1 antibody should be stored long term (months) at -20 grades C and short term (weeks) at 4 grades C. As with all antibodies avoid freeze/thaw cycles.

Properties

If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Antibody advice

PTHR1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, and immunohistochemistry starting at 15 ug/mL.

Antigen

PTHR1 monoclonal antibody was made against a synthetic peptide corresponding to aa 146 - 169 of PTHR1 (Human).

Works with

Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Orangutan, Pig

Suspention, pH, azide

PBS, pH 7.6, 0.07% sodium azide, 30% glycerol

Immuno application

Western Blot, immuno-histo-chemistry

Antigene name

parathyroid hormone 1 receptor

Purity

Protein G Column

Antibodie's label

unlabelled serum

Source

Homo sapiens

Vial with antibody

in solution

Type

Monoclonal

French translation

anticorps

Immunoglobulin

IgG1,k

Omim nr

417555

Ncbi nr

Q03431

Protein nr

Q03431

GENE symbol

PTH1R

Ab raised in

Mouse

NCBI GENE nr

5745

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