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Size
0.1mg
Price
389.00
Catalog
R31182
Quick and safe buy process
Description
A Disintegrin-Like and Metalloproteinase with Thrombospondin Type 1 Motif, 1, also known as METH1, is an enzyme that in humans is encoded by the ADAMTS1 gene. ADAMTS is a family of proteins believed to be anchored to the extracellular matrix(ECM) through interactions with aggregan or other matrix components by one or more thrombospondin type 1 motifs. Scott(2000) mapped the gene to 21q21.2 based on sequence similarity between the ADAMTS1 sequence and a chromosome 21q21.2 clone. Kuno et al.(1997) found that mouse Adamts1 expression could be induced in vitro in colon adenocarcinoma cells by stimulation with the inflammatory cytokine interleukin 1-alpha, or in vivo in kidney and heart by intravenous administration of lipopolysaccharide. Vazquez et al.(1999) determined that ADAMTS1 disrupts angiogenesis in vivo and in vitro more efficiently than ADAMTS8, THBS1, or endostatin.
Storage
After reconstitution, the ADAMTS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
Notes
The stated application concentrations are suggested starting amounts. Titration of the ADAMTS1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Species reactivity
Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
Properties
If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Immunogen
Amino acids 956-968 (KHYIDFCTLTQCS-mouse) were used as the immunogen for this ADAMTS1 antibody.
Intented use
This ADAMTS1 antibodyis to be used only for research purposes and not for diagnostics..
Concentration
0.5mg/ml if reconstituted with 0.2ml sterile DI water
Host animal
Rabbit (Oryctolagus cuniculus)
Clonality
Polyclonal (rabbit origin)
Form
Antigen affinity purified
Recommended dilutions
Western blot: 0.5-1ug/ml
Clone
Polyclonal antibody
Purity
Antigen affinity
Conjugation
Unconjugated
French translation
anticorps
Category
Antibody
Recognised antigen
ADAMTS1
Uniprot #
P97857
Tested applications
WB